Both mean “a large number of” or “a large amount of”
Both expressions can be used with countable and uncountable nouns
Some people say that both expressions are informal. For that reason, it is probably best not to use them in exam situations. More formal expressions include: “a large number of”, “a large amount of”, “many”, “much” and “a great deal of”.
Some people say that “lots of” is more informal than “a lot of”.
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